Serum procalcitonin as a predictor in difficult laparoscopic cholecystectomy for acute cholecystitis patients

Abstract

Nowadays, laparoscopic cholecystectomy is one of the most common surgeries, especially in Iran, and in many cases may lead to open cholecystectomy. The purpose of this study is to determine the relationship between serum procalcitonin levels and turning of laparoscopic cholecystectomy to open cholecystectomy, so that by changing the surgical method, it can reduce complications in patients with acute cholecystitis and improve the quality of life of patients and on the other hand reduce the unforeseen difficulties of surgery for the surgeon.

Data and sampling This study is a retrospective cohort study and the sample size includes patients who underwent laparoscopic cholecystectomy in Sina Hospital in Tabriz due to acute cholecystitis. The sample size is 115 people. After selecting of Patients based on inclusion and exclusion criteria and their screening, all patients information will be extracted and statistically analyzed based on a questionnaire prepared and attached.

Results The sample size of our study is 115 patients. Out of 115 patients, about 40% (46 cases) were in the DLC group (Difficult laparoscopic cholecystectomy) and about 60% (69 cases) were in the NLDC group (Non-difficult laparoscopic cholecystectomy). The mean age in the DLC group was 56.3 ± 15.3 and in the NDLC group was 51.7 ± 13.4. DLC group has higher TG-18 scale, serum procalcitonin level and serum CRP than NDLC group and this relationship is statistically significant (P-value = 0.001). The incidence of gallbladder gangrene in the DLC group was higher than in the NDLC group, and the macroscopic evidence of simple cholecystitis was higher in the NDLC group than in the DLC group (2.2% vs. 29%, P <0.001). Evidence of DLC was higher in patients with serum procalcitonin levels higher than 1.5 ng / ml and this finding was statistically significant (P-value = 0.004).