Predictive value of serum level of NT-pro BNP for determination of outcome in patient with traumatic brain injury

Abstract

In medical terms, trauma is any type of ulcer or penetrating or non-traumatic injury that is caused intentionally or unintentionally by external factors in the human body. In addition to imposing direct and indirect socio-economic costs on society, trauma is known to be the fourth cause of human death in the world. The aim of this study was to evaluate the predictive value of serum level of nt-pro bnp for determination of outcome in patient with traumatic brain injury. Materials and Methods: This is an analytical descriptive study that was conducted for 40 patients with head trauma and brain CT scan indication at Emam Reza Emergency Department of Tabriz during 2016-2017. At the moment of the patient's arrival, an initial assessment and blood sample were taken and brain CT scan was scheduled and the patient was admitted. The variables of study were included age, sex, initial level of consciousness based on GCS, trauma mechanism, trauma interval and referral, mortality, GOS at discharge, one, six and twelve months later, NT-pro BNP level and control brain CT scan results. Results: The mean ± standard deviation of NT-pro BNP values in the normal brain CT-Scan group was 502.53 ± 153.24 pg/mL and abnormal brain CT-Scan group was 128.88 ± 12.4 pg/mL. Significant differences were observed between the two groups (p = 0.002). By determining the mortality rate in the patients, four patients (10%) died during the study. These numbers were abnormal in CT-Scan patients. Also, there was a significant difference in the prevalence of mortality between the two groups (p = 0.011). The diagnostic value of the NT-pro BNP serum level was evaluated in predicting mortality rate using ROC curve, which had an AUC of 0.778 (0.641-0.95, CI 95%). Cut off point of 617 pg/mL was also determined with a sensitivity of 100% and specificity of 66.7%.