Studying the effect of combination topical therapy using three medications (Dorzolamide drops, Ketorolac drops, Prednisolone drops) in treatment of Ivrin Gass syndrome (CME) post cataract surgery

Abstract

Acute PCME may improve on its own, but in some patients it can develop into chronic macular edema and impaired vision, which is also difficult to treat. The goal of any treatment is to reduce macular edema and increase vision. The aim of this study was to evaluate the effect of Combination topical Therapy with three drugs (Dorsolamide drops, Ketorolac drops, Prednisolone drops) in the treatment of macular cystic edema after cataract surgery. Methods and Materials: In this study, which is a clinical trial, patients who entered the study underwent combined topical treatment with ketorolac, prednisolone and dresolamide drops. All drops were administered four times a day, once every 6 hours. Treatment continued for up to 8 weeks after starting treatment. If CME improved before this time, the patient was examined 8 weeks later. The studied variables include patient vision before starting and 8 weeks after starting treatment, IOP before starting and 8 weeks after starting treatment and macular thickness before starting treatment and 8 weeks after starting treatment. Results: In this study, 42 patients with CME with a mean age of 58.86. 5.94 were studied. Which included 22 men and 20 women. The mean macular thickness (central foveal thickness) before treatment was 374.62 44 44.24 μm and after 8 weeks of follow-up was 260.55 6. 6,364 μm, which was statistically significant P = 0.001. Mean visual acuity before treatment was 0.53 ± 0.182 logMar and after 8 weeks of follow-up was 0.46 ± 0.405 logMar which was statistically significant (P = 0.02). Mean mean intraocular pressure (IOP) before treatment 15.88. 15.38 mm Hg and after 8 weeks of follow-up was equal to 2.66 ± 15.95 mm Hg, which was not statistically significant (P = 0.9).