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dc.contributor.advisorHabibi asl, Bohloul
dc.contributor.authorJomeiri, Basira
dc.date.accessioned2022-10-24T06:27:55Z
dc.date.available2022-10-24T06:27:55Z
dc.date.issued2022en_US
dc.identifier.urihttps://dspace.tbzmed.ac.ir:80/xmlui/handle/123456789/67485
dc.description.abstractintroduction: Despite the analgesic effects of morphine, it’s chronic use leads to tolerance and dependence studies indicate that serotonergic and dopaminergic system have important role on morphine induced dependence and withdrawal system. Bromocriptine acts as an agonist of dopamine D2 receptors, and sertraline increases serotonin by inhibiting serotonin reuptake Aim: evaluate possible role of D2 receptor and SSRIs on morphine induced dependence and withdrawal signs.Method: :10 groups of mice containing 9 male mouse (weighing 20-30 g) will randomly select and will give the following doses for 14 days. On the 11th day we will start to give medicine 30 minute before morphine injection. 1)Saline (10 ml/kg , ip) + Saline(10 ml/kg , ip) 2) Saline (10 ml/kg , ip) + Morphine(50 mg/kg , ip) 3)DMSO 20 % + morphine (50 mg/kg , ip) 4,5,6)Sertraline(5 , 10 , 20 mg/kg , ip) + Morphine(50mg/kg , ip) 7,8,9)Bromocriptine(0.04 , 0.08 , 0.16 mg/kg ,ip ) + Morphine(50 mg/kg , ip) 10)Sertraline (5mg/kg ,ip ) + Bromocriptine (0.04 mg/kg , ip ) + Morphine(50 mg/kg , ip) On the 14th day of administrating of morphine, 2 hour after the injection of the last morphine dose naloxone (5mg/kg , ip) will inject in all groups and sign of discontinuation (jumping and standing on both feet) will evaluate.Finally animals will be anesthetized by injection of ketamine (100 mg/kg , ip) and xylazine (10 mg/kg , ip). And blood samples will be taken from the heart to measure serum MDA and TAC levels.Result: Bromocriptine injection and co-injection of bromocriptine and sertraline reduced morphine dependence (p<0.01). And sertraline injection (20mg/kg, ip) caused a significant change in MDA and TAC levels (P<0.01).Conclusion:co-injection of bromocriptine and sertraline before the daily injection of morphine reduced morphine dependenceen_US
dc.language.isofaen_US
dc.publisherTabriz University of Medical Sciences , School of Pharmacyen_US
dc.relation.isversionofhttps://dspace.tbzmed.ac.ir:80/xmlui/handle/123456789/67484en_US
dc.subjectMorphineen_US
dc.subjectsertralineen_US
dc.subjectbromocriptineen_US
dc.subjectaddictionen_US
dc.subjectmale miceen_US
dc.titleEvaluating the effects of serteraline and bromocriptine on morphine induced dependence in male miceen_US
dc.typeThesisen_US
dc.contributor.supervisorAzarmi, Yadollah
dc.contributor.supervisorNajafi, Moslem
dc.identifier.callno4272en_US
dc.description.disciplinePharmacyen_US
dc.description.degreePharm Den_US


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