Title: The effect of oleoylethanolamide supplementation on serum level of Lipopolysaccharide binding protein and genes expression of Myeloid differentiation primary response 88, TIR-domain-containing adapter-inducing interferon-β, Caspase 8, interleukin 1- β in peripheral blood mononuclear cells of obese patients with non-alcoholic fatty liver disease: a double-blinded randomized controlled clinical trial

Abstract

Results: There were no significant changes in mRNA expression of IL-1B, Caspase 8 and MYD88 genes between the two groups even after controlling possible confounders in any of the models. However, a marginal decrease in TRIF expression levels was observed compared to the placebo group (P=0.06). However, there were no significant changes in LBP serum levels between the two groups after controlling possible confounders in any of the models. Compared to the placebo group, the OEA group showed a significant decrease in all anthropometric indices after adjustment for both models at the end of the study. Conclusion: In conclusion this study provides evidence that did not support the beneficial effects of OEA supplementation on pyroptosis pathway. Further studies are needed to confirm our findings. KEYWORDS: Non-alcoholic fatty liver disease, Pyroptosis, Oleoylethanolamide, Obesity, Inflammation