A study on efficacy of ginger on clinical manifestations in patient with Functional Dyspepsia

Abstract

Functional Dyspepsia (FD) is chronic or recurrent pain or discomfort in the upper abdomen for which no structural cause has been found. The treatment approaches available for FD are not satisfactory for most patients. Ginger has been used to treat several digestive problems. Therefore, this study aimed to evaluate the effect of ginger on the clinical symptoms of patients with FD.

Methods: The patients referred to the gastroenterology clinic within two years were selected based on gastroenterologist diagnosis, the ROME IV criteria, and the inclusion and exclusion criteria. H. pylori-positive patients were first treated then entered the study. Selected patients randomly were divided into groups of placebo (n=35) and ginger (n=35). The patients received three capsules of 250mg/day for four weeks. After obtaining informed consent for each participant, patients rated the severity of their symptoms based on the ROME IV criteria.

Results: The mean age of participants was 38.05 ± 11.73 years. The mean epigastric burning sensation score was significantly lower in the ginger powder group compared with placebo (p-value = 0.001). But ginger didn't make statistically significant changes from placebo on postprandial fullness, early satiety, epigastric pain.