Comparison of pain after mandibular impacted third molar surgery following Pregabalin and Acetaminophen: Clinical trial (double blind)

Abstract

Introduction: Postoperative pain is one of the most common complications of third molar surgery. In addition, excessive use of central analgesics can cause adverse side effects. In this study, the effect of pregabalin on pain after surgery and the dosage of analgesics after surgery on the impacted third molar of the mandible was examined. Materials & Methods:This study is a double-blind (patient-researcher) clinical trial (Blinded Parallel Groups Randomized Clinical Trial) using the Splite mouth method after the approval of the Ethics Committee (code IR.TBZMED.REC. 1401.290) and registration in the Clinical Trial Center of Iran (code no. IRCT (IRCT20220316054314N1) was performed on patients who needed surgery on the mandibular impacted third molar in two groups of acetaminophen and pregabalin. Patients were selected according to the inclusion criteria.The control group (32 people) and the intervention group (32 people) on both sides of the third molar of the mandible for Extraction,One hour before the surgery, according to the principles of blinding, one of the two drugs pregabalin 150 mg and acetaminophen 650 mg was given to the patient. Inferior alveolar and long buccal nerve block was performed by a single surgeon. A circular incision was made with distal extension, and after removing the alveolar bone, the tooth extracted and flap was turned back and sutured. The pain level was recorded using the VAS scale, at the end of the surgery, 6 hours and 24 hours after the end of the surgery. One month later, the second surgery was performed on the opposite side with the same method by the same surgeon. SPSS 21 statistical software was used to analyze the data. Results:Pregabalin delayed the onset of pain and accelerated the end of pain. The survival time of supplemental analgesic consumption in the pregabalin group reached zero at 16 hours after surgery, but in the acetaminophen group, it continued until 22 hours after surgery. The average consumption of supplemental analgesic at 4, 10, and 12 hours after surgery was significantly lower in the pregabalin group than in the acetaminophen group. Conclusion:Administering a single dose of 150 mg oral pregabalin one hour before third molar surgery can reduce pain and reduce the dosage of additional analgesics.