Evaluation of the effect of penetration enhancers on transdermal absorption of Cladribine

Abstract

Cladribine is one of the drugs used in chemotherapy by injection and one of the oral anti- MS drugs with immune system blocking effects. Many studies have not been done on the skin absorption of this drug, so the study of the skin absorption of this drug is innovative Aim: Investigating the effects of increasing skin absorption of several absorption-enhancing substances for topical use in autoimmune skin diseases.Materials and Methods: Preparing different concentrations of absorption enhancers along with the drug, carrying out in vitro skin absorption on the skin of rats by the Franz cell device and determining the amount of drug that passed through the skin and entered the receptor compartment of the Franz cell device using high performance liquid chromatography. (HPLC) in the presence of different types of absorption enhancers with different concentrations and analyzing the data obtained from the skin absorption tests and drawing conclusions from the data and finally preparing a general work report on the design and writing of the relevant article . Results: Cladribine in the form of a 2% cream formulation, along with the skin absorption enhancers Transcutol P and Brij 35 with different concentrations, has been able to pass through the stratum corneum better than the 2% formulation of only the drug.Conclusion: By examining the skin absorption results of cladribine in rats, the use of the appropriate type and concentration of absorption enhancers increases the absorption of the drug and its therapeutic effects in autoimmune skin diseases.