Show simple item record

dc.contributor.authorAzizi, Nassim
dc.date.accessioned2022-08-09T03:48:09Z
dc.date.available2022-08-09T03:48:09Z
dc.date.issued2022en_US
dc.identifier.urihttp://dspace.tbzmed.ac.ir:80/xmlui/handle/123456789/66900
dc.description.abstractTo date, beneficial effects of swimming training have been shown in different inflammatory condition such as diabetes. However, the precise mechanism by which swimming training exerts its therapeutic effect has not yet been determined. Therefore, the current study was conducted to investigate the effects of swimming training on apoptosis -related genes in lung tissue of type -1 diabetic mice. Methods: In this study, thirty-two male mice were allocated into four groups; Control group (C), Swimming group (Swimming), Diabetic group (D) and Diabetic + EX (D+ EX) group. In diabetic groups, for induction of diabetes, a single dose of streptozotocin (50 mg / kg) was injected intraperitoannally. Two weeks ofter induction of diabetes, swimming training was performed three times per week for four weeks. Forty-eight hours after the last swimming training, the animals were sacrificed and their lung tissue was obtained. Pathological injuries were assessed using H&E staining. The expression of IL-1β and apoptosis -related genes was measured using real-time PCR assay. Results: Histological examination revealed the promotion of pathological changes in lung tissue of diabetic groups coincided with the up-regulation of IL-1β, Caspase-3 and Bax and up-regulation of Bcl-2 compared to the C group. Swimming training improved diabetic-induced changes.en_US
dc.language.isofaen_US
dc.publisherTabriz University of Medical Sciences, Faculty of Medicineen_US
dc.relation.isversionofhttp://dspace.tbzmed.ac.ir:80/xmlui/handle/123456789/66899en_US
dc.subjectMiceen_US
dc.subjectType -1 diabetesen_US
dc.subjectSwimming trainingen_US
dc.subjectApoptosisen_US
dc.subjectLung tissueen_US
dc.titleThe effect of swimming training on the oppoptosis in lung tissue of type-1 diabetic miceen_US
dc.typeThesisen_US
dc.contributor.supervisorAhmadi, Mahdi
dc.contributor.supervisorMirzaei Bavil, Fariba
dc.identifier.docno6010529en_US
dc.identifier.callno10529en_US
dc.description.disciplineMedicineen_US
dc.description.degreeMD Degreeen_US


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record