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dc.contributor.authorFathi Maroufi, Nazila
dc.date.accessioned2022-05-28T07:20:09Z
dc.date.available2022-05-28T07:20:09Z
dc.date.issued10418en_US
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/66731
dc.description.abstractThe vasculogenic mimicry (VM) is one of the most important causes of breast cancer metastasis and drug resistance. In this study, the effects of melatonin and apatinib on the formation of VM by breast cancer stem cells were investigated. Methods: The effects of apatinib, melatonin and melatonin / apatinib combination on proliferation, viability and formation of VM in MDA-MB-231 stem cells were investigated. In addition, the expression levels of proteins involved in the proliferation, survival of cancer cells and VM formation were examined by Real-Time and Western blotting. Results: Melatonin and apatinib reduced the survival rate of cancer stem cells dose and time dependent manner. Apatinib, melatonin and apatinib / melatonin combination inhibited the proliferation of breast cancer stem cells (P≤0.001). The formation of VM decreased in the MDA-MB-231 cancer cell line treated with apatinib and apatinib / melatonin (P≤0.01). Apatinib and apatinib / melatonin reduced the invasion of breast cancer stem cells (P≤ 0.0001). VE-cadherin, EPHA2 expression and p-PI3K / PI3K and p-AKT / AKT ratios decreased under the treatment of apatinib and apatinib / melatonin (P≤0.01).en_US
dc.language.isofaen_US
dc.publisherTabriz University of Medical Sciences, Faculty of Medicineen_US
dc.relation.isversionofhttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/66730en_US
dc.subjectApatiniben_US
dc.subjectBreast canceren_US
dc.subjectCancer stem cellsen_US
dc.subjectMelatoninen_US
dc.subjectVasculogenic mimicryen_US
dc.titleThe Effect of Melatonin and Apatinib on the Vascologenic Mimicry by Cancer Stem Cells from Breast Cancer Cell Lineen_US
dc.typeThesisen_US
dc.contributor.supervisorNouri, Mohammad
dc.contributor.supervisorRashidi, Mohammad-Reza
dc.identifier.docno6010418en_US
dc.identifier.callno10418en_US
dc.description.disciplineClinical Biochemistryen_US
dc.description.degreePh. Den_US


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