Predictive value of serum level of B type natriuretic peptide (BNP) in neonatal sepsis

Abstract

The aim of this study was to investigate the relationship between serum natriuretic type B peptide level and neonatal sepsis. Materials and Methods: In this case-control study, all full-term and pre-term neonates who were admitted to a children's hospital with a diagnosis of sepsis (from the date of plan approval until the sample size was completed) and a septicemia diagnosis were confirmed after obtaining consent. The study was deliberately entered from the patient's parents or legal guardian. CBC/Diff - CRP - B/C - U/A-U/C - NT-pro BNP were checked and finally compared with laboratory results of the same number of infants who did not have clinical and laboratory symptoms of sepsis. After collecting samples, laboratory results including serum levels of NT-pro BNP were compared in case and control groups. Results: A total of 100 patients were studied in two groups. 38 patients (38%) were boys and 62 patients (62%) were girls. The mean age of the patients was 7.58±7.46 days with a median of 4 days. The minimum age of patients was 3.5 days and the maximum was 29 days. The mean weight of the studied patients was 2811.80±620.33 g with a median of 2855 g. The most common clinical symptom observed in patients in the case group was fever (100%) followed by Poor feeding (84%). In the control group, all patients had jaundice. Neonates with sepsis had significantly higher initial pro-BNP values compared to the control group (10023.80 vs. 2247.20; p=0.001). The NT-pro BNP level cut-off point in predicting the final treatment status and mortality of neonates with sepsis was 9583 pg/ml with 97.7% sensitivity and 93.6% specificity.