Effect of a probiotic supplementation, Lactocare, on gut microbiota in critically ill septic patients admitte to intensive care units

Abstract

In this study we aimed to explore the Effect of lactocare on gut microbiota in critically ill septic patients admitted to intensive care unit. Methods and Materials: Forty adult patients with the diagnosis of sepsi were enrolled in this pilot randomized trial. Patients were randomized two 2 groups: lactocare and standard treatment. Patients in lactocare group received 2 capsuls of lactocare for 10 days. Fecal samples were taken from all patients on day 1 and 10 for determining the gut microbial

pattern. Primary outcome was gut microbial flora and secondary outcomes were ICU length of stay and mortality. Results: Regarding the gut microbiota in 10th day our results showed that the colony count of all flora was significantly higher compared to control group. Regarding the microbial changes between day 1 and day 10 between two groups our results showed that a higher number of all microbial flora in Lactocare group except for bifidobater, atopobium and enterobacteriacea. Intragroup changes in two groups between day 1 and day 2 showed that all microbial flora changes significantly during the study period which the number of microbial flora decreased significantly in control group and increased significantly in Lactocare group. Patients in the lactocare group had a significantly lower incidence of diarrhea and infection with multi drug resistant drugs. Mortality rate was 30% in control group compared to 20% in lactocare group which was not significant (p: 0.465).