Comparison of level of C-reactive protein (CRP), lipid profile, bone densitometry, vitamin D and glucose in serum of patients with primary hyperparathyroidism before and after parathyroidectomy

Abstract

Primary hyperparathyroidism (PHPT) increases the risk of cardiovascular disease, but the role of calcium and parathyroid hormone is still controversial. In recent years, special attention has been paid to assessing the prevalence of metabolic syndrome markers, serum vitamin D levels, as well as femoral neck densitometry, before and after parathyroidectomy. Data and sampling In this cross –sectional study, 60 patients with primary hyperparathyroidism scheduled for parathyroidectomy. Acute inflammatory phase protein, total cholesterol, LDL and HDL lipoprotein level, fasting blood sugar, serum level of glycosylated hemoglobin and parathyroid hormone and bone mineral density of lumbar spine and femur before parathyroidectomy were evaluated. Evaluation of the mentioned factors was performed with venous blood samples of patients before and after parathyroidectomy. Bone density of spine and femur was assessed by bone densitometry. The above factors were evaluated six months after surgery. Then the statistical data obtained from the study were statistically analyzed. Results Of 60 patients, 18 patients were male (30%) and 42 patients were female (70%). The mean age of all participants was 12 ± 54 years. Biochemical indices such as HDL, LDL, total cholesterol, and serum glucose as well as glycosylated hemoglobin levels in patients with PHPT were improved after parathyroidectomy, but this improvement was not statistically significant. In contrast, serum levels of ionized calcium and CRP as well as serum levels of parathyroid hormone and Vit-D3 in patients after parathyroidectomy were significantly reduced, which was statistically significant. Parathyroidectomy in these patients was associated with an increase in BMD in L.S (2.5 ± 0.56 and P≤0.001) and F.N (2.1 ± 0.62 and P≤0.001). This improvement in BMD in patients was statistically significant. Improvement of bone density in these patients was significantly associated with improvement in CRP as well as normalization of serum calcium levels and parathyroid hormone levels.