The comparison of the effect of tetracycline sterile ophthalmic ointment as an adjuvant to mechanical debridement and mechanical debridement alone in peri-implantitis treatment

Abstract

Introduction: Peri-implantitis is an infectious disease that affects the tissues around dental implants and presents with clinical signs of inflammation and irreversible loss of supporting bone. Several assisted cleansing techniques have been used in the surgical treatment of peri-implantitis, including saline or chemicals and photodynamic therapy. Tetracycline is an antibiotic that has been used effectively in the treatment of periodontitis and is particularly effective on bacteria. The present study aimed to compare the effect of tetracycline sterile eye ointment topically as an adjuvant to mechanical debridement with mechanical debridement alone in the treatment of peri-implantitis. Materials and Methods: In this single-blind randomized clinical trial, 32 patients (16 patients in each group) with peri-implantitis were treated topically using tetracycline sterile eye ointment. Patients aged 20 years and older with peri-implantitis and at least one implant with PD> 6 mm, also with BOP positive and radiographic bone loss, were included in the study. Four clinical findings, including mBI - mPI - PD - CAL, were measured at the beginning of the study and during one and 3-month follow-up. Results: The study's results using the Student's t-Test showed that the study variables (PD reduction in the intervention group after 3 and 6 months by 2.06±0.92 mm and 3.56±1.20 mm, respectively, and in the control group by 1.37±1.08 mm and 2.62±1.02 mm, respectively; The rate of mPI reduction in the intervention group was 1.18±0.91 and 1.43±0.89, respectively, and in the control group was 1.00±0.73 and 1.62±0.88, respectively; The rate of mBI reduction in the intervention group was 0.42±0.46 and 0.5±0.28, respectively, and in the control group was 0.19±0.29 and 0.29±0.11, respectively) have significant differences after 3 and 6 months. In all samples in the two groups, the mean of CAL before and after treatment was constant and there was no statistically significant difference (p>0.05). The paired-Sample t-test also showed that the results obtained in the two groups were not statistically significant, although the results were better in the intervention group (using eye ointment). Conclusion: The present study results showed that using sterile ocular tetracycline ointment could be an adjunctive treatment in improving and enhancing the therapeutic effects of mechanical debridement in the treatment of pre-implantitis.