| dc.description.abstract | Background: Periodontitis is a chronic inflammatory disorder that affects the tissues surrounding the teeth. Many factors contribute to the disease. In this study, Ferritin, Zinc, and Calcium serum levels were compared with disease severity in individuals with disseminated chronic periodontitis.
Materials and Methods: In this cross-sectional descriptive study, the 48 periodontitis patients who meet the inclusion criteria was investigated. After obtaining informed consent, a checklist including age and sex and the results of clinical examinations to determine the severity of periodontal disease and serum levels of ferritin, zinc, and calcium was prepared. Clinical examinations of patients include the number of teeth, pocket depth probe (PD), clinical adhesion level (CAL), plaque control registration, and bleeding points. Based on the degree of clinical adhesion, patients are classified into three groups (mild, moderate, and severe). Then a serum sample was received from the patients. In the laboratory, the serum sample is centrifuged at 4000 rpm for 8-10 minutes. Serum samples are stored at -20 ° C until testing. ELISA method and diagnostic kits of each variable were used to measure serum Ferritin, Zinc, and Calcium levels. Results are presented in nanograms per milliliter. As a result of Kolmogorov-Smirnov tests, parametric tests for ferritin and serum calcium of patients were used and non-parametric tests for Zinc, to analyze the relationship between severity of periodontitis and these variables. SPSS software version 24 was used for data analysis. A probable value less than 0.05 is considered a significant level.
Results: It was found that 37.5% of the patients with mild periodontitis were female and 62.5% were male. When it comes to patients with moderate periodontitis, 68.8% are female and 31.2% are male, and when it comes to patients with severe periodontitis, 31.2% are female and 68.8% are male. In patients with mild periodontitis, the mean ± SD age was 34.81 ± 6.10 years, in those with moderate periodontitis, 34.43 ± 4.66 years, in those with severe periodontitis, 61.81 ± 2.56 years. In patients with mild, moderate, and severe periodontitis, the mean serum ferritin levels were 206.12, 103.41, and 88.41, respectively, and the mean serum zinc levels were 93.0, 79.81, and 76.06, respectively, and the mean serum calcium levels were 9.87, 9.60, and 9.37. According to the statistics, the serum levels of ferritin, zinc, and calcium were significantly different depending on the severity of periodontitis (P-Value <0.05).
Conclusion: In the current study, the mean serum level of ferritin, zinc, and calcium decreased with increasing periodontitis severity and was associated with a downward trend. | en_US |
