Diagnostic value of IL-27 and ADA in differentiating of tuberculous and pleural malignancy

Abstract

Tuberculosis is one of the main causes of morbidity and mortality, especially in Asia and Africa with high prevalence. TPE is a common extrapulmonary manifestation of tuberculosis. It frequently causes pleural effusion, especially in areas with a high prevalence of tuberculosis. The present study was designed and performed to determine the value of interleukin-27 and adenosine deaminase in the differential diagnosis of tuberculosis from pleural malignancy.

Materials and Methods: In this cross-sectional study, patients with exudative pleural effusion who were admitted to Imam Reza Hospital in Tabriz in 2020-2021 were studied. Inclusion criteria include the presence of exudative pleural effusion, admit in the period of March 2020 to March 2021 and informed consent to participate in the study and exclusion criteria include no final diagnosis for the patient despite examinations, diagnosis of exudative pleural effusion caused by factors other than tuberculosis and malignancy, lack informed consent to participating in the study and incompleteness of required information, non-exudative pleural effusion and admit in the period ecxept of March 2020 to March 2021.

Results: The mean age of patients in the present study was 50.96 years. Among the patients, 61.3% were male. Levels of IL27, ADA, WBC, LDH and protein in pleural fluid in TPE patients were significantly higher than MPE (P <0.05). The best diagnostic test for MPE from TPE was PADA × ILK27 (cut off 4675 with sensitivity of 100% and specificity of 95% with P <0.0001).