The effect of Na- selenite, and Na- selenite -enriched yeast supplementation on lipid profile, oxidative status, and nitric oxide in patients with coronary artery diseases.

Abstract

Abstract Background: Experimental studies have shown that selenium is involved in the synthesis of selenoproteins which might contribute to cardiovascular protection. The impact of selenium on coronary artery disease (CAD) remains unclear with inconsistent results from observational studies and randomized controlled trials. In this study we assessed the effect of selenite-sodium enriched yeast and selenite sodium supplementation on lipid profile, glycemic profile and oxidative status in patients with coronary artery diseases. Material and Methods: A double-blind randomized clinical trial was performed in which patients (n = 49) were divided to 3 groups. Group 1(n=17 )was treated with 200µg selenite-sodium, group 2 (n=16)was treated with 200µg selenite-sodium enriched yeast and group 3 (n=16)was received placebo for 8 weeks. The following parameters were analyzed before and after the intervention. Anthropometric measurements, blood pressure, glycemic status and lipid profiles and MDA, GPx, SOD and NO were carried out using standard protocols. Results: We found that Serum LDL levels in selenium supplementation groups were significantly lower than the placebo group at the end of the study, but the levels of other parameters of the lipid pattern did not show a significant difference (P <0.05). Selenium intake had no significant effect on glutathione peroxidase (GPX), malondialdehyde (MDA) and nitric oxide (NO) and only serum SOD level in sodium selenite group increased significantly compared to before supplementation (P <0.05). Fasting insulin and glucose (FBS) and glycosylated hemoglobin (HA1c) levels in the intervention groups before and after the intervention did not show any significant difference (P <0.05). Conclusion: Due to beneficial effects of supplementation of yeast enriched with sodium selenite (preventing an increase in serum LDL levels) and sodium selenite supplementation on increasing serum SOD levels compared to before the intervention, in addition to no significant change in other parameters, further studies with control of Confounding factors such as dietary intake and level of physical activity are needed. Key words: Selenite-sodium, yeast, supplementation, coronary artery diseas