Evaluation of serum LDH levels in patients with suspected sepsis and its relation to outcome of disease

Abstract

Sepsis is a systemic inflammatory response to infection and its complications developmental stages of the same disease complications in the systemic response to infection by endogenous mediator of inflammation may be made public. Lactate dehydrogenase is also an inflammatory biomarker that in many cases increases and an increase in the incidence of sepsis can be a valuable diagnostic and predictive. The aim of this study was to evaluate the diagnostic significance of serum lactate dehydrogenase as a test is relatively inexpensive and available in patients with sepsis Materials and Methods: 200 adults SIRS positive evidence of the presence of the infectious agent, or blood culture positive urine culture, evidence of pneumonia on chest radiography, analysis of cerebrospinal fluid is suggestive of meningitis or WBC in stool exam, were enrolled. People with a history of malignant disease, hemolysis, trauma and recent surgery, a history of heart failure and ischemic heart disease. Negative blood cultures or urine after 72 hours were excluded. Serum LDH levels at admission and during hospitalization were also explored. Results: Among the 201 patients, 106 cases of sepsis, severe sepsis 56 cases, 33 cases of septic shock and multi-organ failure were diagnosed in 6 patients. Also, patients clearance of 85 people, 82 people died and 34 were hospitalized. The high rate of mortality in patients with severe sepsis degrees, respectively. Between LDH and other inflammatory elements such as white blood cell count, platelet count and changes in the average volume of red blood cells was positively correlated. As well as significantly blood LDH levels in patients in our study were higher than other patients.