Cotargeting of HIF-1alpha and IL-6 for blocking the growh and development of cancer cells

Abstract

The use of fast and rapid tumor cells causes tumor cells to form in the tumor area and if anti-tumor tumor cells inhibit T and NK cells. According to studies, the most active factor in these conditions is HIF-1a, which causes tumor cells and is allowed based on metastasis, angiogenesis and tumor drug resistance. HIF-1a can also express IL-6, and adenosine-rich conditions are created in the environment that play an important role in the mechanism of tumor escape. Separate studies have been performed only to inhibit HIF-1a and IL-6 due to the lack of side effects.

Materials and Methods: In this study, with the help of interfering nanoparticles and siRNAs, we sought to introduce a targeted method that suppresses the expression of HIF-1a and IL-6 genes simultaneously for the first time in tumor microenvironment and at low doses, Have the most impact and the least complication. Therefore, siRNA-loaded nanoparticles were used to suppress the expression of the above factors in 4T1 mouse breast cancer cells.

Results: The results of this study showed that combination therapy using nanoparticles loaded with siRNA molecules can reduce the survival of cancer cells and inhibit the proliferation of cancer cells and suppress the expression of tumor-promoting genes.