Evaluation of interleukin 17 gene polymorphism rs763780 in kidney recipients with post-transplant diabetes

Abstract

The aim of this study was to evaluate the rs763780 polymorphism of IL-17F gene in transplant patients with and without PTDM. Material and methods. This study was performed on 91 patients who have had a kidney transplant for at least 3 months. Patients were divided into two subgroups: patients with PTDM (n = 32) and patients without PTDM (n = 59). After DNA extraction from patients' blood samples, amplification and evaluation of specific polymorphism of the gene were performed using ARMS-PCR. Clinical and demographic data of patients were collected. Data analysis was performed using SPSS software (version 23). Results. PTDM was detected in 81.3% (n = 26) of TT genotype carriers, 12.5% of TC genotype carriers, and 6.3% of CC genotype carriers. There was no statistically significant difference between the case and control groups in the frequency of T and C alleles and the distribution of the abovementioned genotypes (P≥ 0.721). In PTDM group, graft rejection and age of patients was significantly higher (P ≤0.017).