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dc.contributor.advisorNariman Saleh Fam, Ziba
dc.contributor.authorGhaffari Aghdam, Amirhossein
dc.date.accessioned2021-12-20T08:59:34Z
dc.date.available2021-12-20T08:59:34Z
dc.date.issued2021en_US
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/65764
dc.description.abstractGlycogen synthase kinase-3 (GSK-3β) is a serine/threonine kinase with multifunctions in various physiological procedures. Aberrant level of GSK-3β in kidney cells has important role in podocyte injury. Therefore, the of this study was measurement of the expression level of GSK-3β measured in peripheral blood mononuclear cells (PBMCs) of patients with the most common types of nephrotic syndrome (NS); focal segmental glomerulosclerosis (FSGS) and membranous glomerulonephritis (MGN). Material and methods 52 NS patients along with 24 healthy individuals were included in this study based on the defined including criteria. GSK-3β expression level were investigated with quantitative real-time PCR (qRT-PCR) method. Results The obtained results showed that GSK-3β expression level in blood cells of NS (P = 0.001), MGN (P = 0.002), and FSGS (P = 0.015) groups have statistically significant increases in compared to the control group. In addition, receiver operating characteristic (ROC) curve analysis approved diagnostic power of GSK-3β in discriminating patients from healthy controls (AUC: 0.72, P = 0.002) with high sensitivity and specificity.en_US
dc.language.isofaen_US
dc.publisherTabriz University of Medical Sciences, Faculty of Medicineen_US
dc.relation.isversionofhttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/65763en_US
dc.subjectFocal Segmental Glomerulosclerosis (FSGS)en_US
dc.subjectGlycogen synthase kinase-3 (GSK-3β)en_US
dc.subjectMembranous glomerulonephritis (MGN)en_US
dc.subjectNephrotic syndrome (NS)en_US
dc.subjectProteinuriaen_US
dc.titleEvaluation of glycogen synthase kinase 3β gene expression levels in blood samples of with patients with primary nephrotic syndrome and its association with response to glucocorticoids therapyen_US
dc.typeThesisen_US
dc.contributor.supervisorZununi Vahed, Sepideh
dc.contributor.supervisorArdalan, Mohammadreza
dc.identifier.docno6010165en_US
dc.identifier.callno10165en_US
dc.description.disciplineMedicineen_US
dc.description.degreeMD Degreeen_US


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