The effect of curcumin supplement on anthropometric, quality of life, repeat of pulmonary infections, hospital admissions and antibiotic use in children with cystic fibrosis

Abstract

The aim of this study was to determine the effect of curcumin supplement on anthropometric, quality of life, repeat of pulmonary infections, hospitalization and antibiotic use in children with cystic fibrosis. Materials and Methods: This is a double blind clinical trial study (IRCT2016022826798N1). The study population included 40 patients with cystic fibrosis, diagnosis based on clinical evidence (osteoarthritis, nasal polyps, rectal prolapse, history of ileus meconium and recurrent pneumonia), laboratory findings (sweating test greater than 60 mEq/dL) or genetic review (presence of mutations in the CFTR gene) is confirmed and refers to gastrointestinal sections and clinics. These children entered the study after having obtained entry and exit criteria and informed consent. Results: The rate of improvement in anthropometric indices was observed in 15 patients (37.5%) and 12 (30%) in the placebo group (p = 0.016). The reduction in diarrhea was observed in 16 patients (40%) and in the placebo group in 15 patients (37.5%); but there wasn’t significant correlation (p = 0.705). The reduction in the number of hospital admissions was observed in the patients receiving the drug in 15 cases (37.5%) and in the placebo group in 10 (25%) cases (p = 0.122).