Evaluation of the relationship between Serum and saliva levels of phosphorus and glucose in healthy patients referred to Tabriz Dentistry Faculty

Abstract

Introduction: The use of salivary compounds due to non-invasiveness has provided a suitable tool for the replacement of blood components. Due to the importance of phosphorus and glucose levels in many biological processes, this study evaluated the relationship between serum and salivary levels of phosphorus and glucose in healthy patients referred to Tabriz Dentistry Faculty. Methods: This descriptive study was conducted on 40 patients referring to Tabriz Dental School. The salivary and serum sample of patients were extracted according to standard protocols. Data was presented as mean (± standard deviation) and frequency (percentages) for quantitative and qualitative variables, respectively. Statistical analysis by SPSS19 software. To determine the correlation between serum and salivary levels of biomarkers Pearson test was performed by SPSS 24 software. The level of P <0.05 was considered significant. Results: From 40 subjects who were studied 22 were women and 18 were men. The average for salivary phosphorus level was (20.5 mg/dl) , which was higher than the average of serum phosphorus (3.6 mg/dl ),and on the contrary , and the average of salivary glucose level was (3.4 mg/dl) ,which was less than the average serum glucose level (88.9 mg/dl) .The result of paired samples T test ( p-value<0.05) showed that there is a statistically significant difference between the mean of serum phosphorus and salivary phosphorus,as well as between the serum glucose and salivary glucose levels. Pearson correlation test results showed that there is no significant correlation between serum and salivary phosphorus level(p-value>0.05) , but there is a positive correlation between serum and salivary glucose levels(p-value<0.001) The salivary phosphorus levels was higher than it’s serum but it was the opposite about glucose. {mean salivary phosphorus 20.5 mg/dl - mean serum levels phosphorus 3.6 mg/dl –mean salivary glucose 3.4 mg/dl – mean serum glucose 88.9 mg/dl } Conclusion: It is important to measure accurately the blood factors with the least damage to patients. The study found that there was a statistical relationship between salivary and serum glucose level of healty individuals. In future, salivary samples can be used to measure glucose in these individuals.