The association of two single nucleotide polymorphisms of FOXP3 gene (rs3761548 and rs3761547) with renal allograft function and survival in kidney transplant recipients

Abstract

Kidney transplantation is a suitable alternative treatment for patients with end-stage renal failure (ESRD) and is associated with improved survival, improved quality of life, and reduced treatment costs over time compared to dialysis. Since chronic graft rejection and renal failure are two of the most important causes of long-term renal transplant dysfunction, identifying markers associated with acute and chronic renal transplant rejection as well as its diagnostic markers will be very useful. Therefore, in order to investigate the association of Foxp3 genetic polymorphisms with renal function, survival and rejection, the present study aimed to investigate the association between two single nucleotide polymorphisms of FOXP3 gene (-3499T / C and -3279 C / A) with function and survival Renal transplantation was planned in patients. Target population and methods: Evaluation of the association between these two polymorphisms, located in the promoter region of the FOXP3 gene, with the function and survival of 150 renal transplant patients who had undergone kidney transplantation at Imam Reza Hospital in Tabriz at least three years ago, was examined at this study. Genotyping was performed by PCR-RFLP method. Findings and Conclusion: Based on the findings of the present study, serum creatinine level and GFR as an indicator of kidney function, 3 and 5 years after kidney transplantation, respectively, were not correlated with the polymorphisms of the sites studied (P> 0.05). Also, based on the correlation coefficient (beta) values, due to the low coefficient values (0-0.2), the relationship was clinically weak and nonsignificant.