Evaluation of the IGF Family genes expression level in AML in comparison with control samples

Abstract

Multiple factors, including growth factors, are shown to be culprits of cancer outset and persistence. Among growth factors, insulin-like growth factors (IGFs) family are of more importance in the prognosis of blood malignancies. After binding to their corresponding receptor, IGFs initiate PI3K/AKT signaling pathway and increase the translation of intracellular proteins, such as cell division-related proteins. They also stimulate the transcription of cell division-related genes using Ras-GTP pathway. In addition to organs such as liver, IGFs are secreted by tumor cells and are able to cause growth and proliferation of self or tumor cells via autocrine and paracrine methods. Current studies indicate that decreasing the effects of IGF by blocking them, their receptors, or PI3K/AKT pathway using various drugs could help suppressing the division of tumor cells. Here, we delineate the role of IGF family in hematologic malignancies and their potential mechanisms. Methods: In the present investigation, we aimed to quantify the expression level of the IGF Family in AML patients and control samples. Results: IGF1, IGF1R and IGFBP3 expression levels were significantly changed in AML patients in comparison with control samples with P.value = =<0.0001, 0.0252, <0.0001 respectively.