Investigation of serum levels of lipocalin2 and amyloid beta in Alzheimer Patients with and without vitamin D deficiency

Abstract

bstract Backgrounds and aims: Vitamin D deficiency is common in the elderly with 65 years and older and is associated with brain changes and dementia, Amyloid-beta (Aβ42) is one of the main plaques of aging and the main pathogenic peptide in patients with dementia. Lipocalin2 (LCN2) is also considered an effective pro-inflammatory mediator in neuroinflammation. Therefore, the aim of this study was to determine and compare serum levels of LCN2 and Aβ in Alzheimer's patients with sufficient and insufficient serum levels of vitamin D. Methods: In this comparative cross-sectional study, 60 patients with Alzheimer's disease (AD) from both sexes (65-75 years) and 29 healthy individuals were selected. Participant’s anthropometric indices, physical activity, dietary intake, mental and cognitive status, degree of unrest, and anxiety were assessed with relevant questionnaires. Serum levels of vitamin D, LCN2, and Aβ were also measured by ELISA method. Results: Body mass index (BMI) in the patient group was significantly lower than the control group (p = 0.04). Serum LCN2 levels in the patient group were lower than the control group (p = 0.02), but there was no significant difference between