Investigation effect of oral paracetamol in closing PDA in premature neonates

Abstract

In this study, the effect of oral Acetaminophen on the closure of PDA in preterm infants was investigated.

Methodology and Materials: The present study was a clinical trial and it was started after approval by the Research Council of the Faculty of Medicine of Tabriz University of Medical Sciences and licensed by the Ethics Committee of the University. 90 premature infants less than 32 weeks of age were randomly assigned into two oral ibuprofen treatment arms and oral acetaminophen by computer software RAND LIST. Oral Ibuprofen was given at a dose of 10 mg / kg in the first 10 days and 5 mg / kg in the second and third day. Acetaminophen was given at a dose of 10 mg / kg q6hr for three days. The success rate was considered to be the closure of the artery duct. Results: In this study, 90 neonates with PDA with less than 32 weeks of gestation were enrolled. The mean ± standard deviation of the gestational age of neonates in the Briefen group was 29.02 ± 1.81 weeks and the acetaminophen group was 28.95 ± 1.66. 37 neonates were males and 53 females. 66 cases (73.3%) of the newborns were from cesarean delivery and 26 cases (26.7%) were the result of normal delivery. The success rate was considered to be the closure of the artery duct. The closure of the arterial duct was 37 cases (82.2%) in the Acetaminophen group and 41 cases (91.1%) in the Ibuprofen group.