A comparison of the effect of intravenous diphenhydramine and ondansetron on post middle ear surgery nausea and vomiting

Abstract

Postoperative nausea and vomiting (PONV) is a common complication after anaesthesia in patients undergoing middle ear surgery that can delay discharge from the post-anesthesia care unit and increase unforeseen hospital admissions. At present in our country there is no guidelines for management of post-operative PONV and the use of antiemetic drugs. so the present study, we discussed the therapeutic effects of intravenous ondansetron and diphenhydramine for preventing nausea and vomiting after middle ear surgery so that We can reduce postoperative nausea and vomiting by anesthesia and drug interventions. Methods: 100 patients undergoing middle ear surgery were randomly divided into two groups (50 patients each). Group 1 received 4 mg intravenous ondansetron before induction of anesthesia and group 2 received 50 mg intravenous diphenhydramine. Blood pressure, heart rate, oxygen saturation level, presence and severity of nausea and vomiting were evaluated in both groups Data were analyzed by SPSS version 20. A P-Value of < 0.05 was considered as statistically significant. Results: Patients did not differ significantly in terms nausea and vomiting. The PACU length of stay was significantly longer in the diphenhydramine group (p =0.03). There was a significant increase in the hemodynamic variables of systolic, diastolic blood pressure and heart rate after injection of antiemetic drug in the diphenhydramine group (p = 0.001).