Determining assosiation between dietary inflammatory index and anthropometric status and metabolic parameters in hemodialysis

Abstract

t: Introduction: Chronic kidney disease (CKD) occurs with progressive and irreversible destruction of nephrons and with dialysis or kidney transplantation is treated in the advanced stages of the disease. In hemodialysis patients, inflammatory factors in the body increase. Inflammatory factors predispose patients to vascular inflammation and lipid disorders which ultimately increase the incidence of cardiovascular disease. The nutritional and diet therapy along with drug strategies has always been used to control hemodialysis. In previous studies, dietary factors such as fiber intake, fruits and vegetables, and antioxidant compounds, etc. have been studied. The study on the inflammatory index of diet and its relationship with anthropometric variables and metabolic parameters was low, so in this study we investigated the relationship between inflammatory index of diet, anthropometric status and metabolic parameters in hemodialysis patients. Materials and Methods: In this cross-sectional study, 81 hemodialysis patients from Labbafinejad Hospital in Tehran were studied according to inclusion and non-inclusion criteria. Data of the last year food intake were collected through a 147 item semi-quantitative food frequency questionnaire (40) through face-to-face interviews. The inflammatory diet was evaluated by Shivapa model. Also, anthropometric indices (weight and body mass index after dialysis) and metabolic parameters (biochemical factors CRP, creatinine, urea, uric acid, lipid profile and fasting blood sugar) were measured under standard conditions. Results: The mean body mass index was 26.4 9 2.9 kg / m2 and there was no significant difference between men and women. The mean inflammatory index of diet in the whole population was -0.06 1.27 which in comparison with men and women, men had anti-inflammatory diet pattern (-0.33 32 1.32) and women had pre-inflammatory diet pattern (32 ± 1.11 / 0). The average energy intake was significantly higher than the average energy requirement and the intake values of macronutrients were in the recommended range. Also, the average intake of fiber and carbohydrates in men was significantly higher than women. The mean daily intake of iron in the study population was significantly higher than the recommended values and the mean calcium intake was significantly lower than the recommended values. Mean daily intake of vitamin B9, calcium, iron and potassium was significantly higher in men than women. Also, no significant relationship was observed between metabolic parameters (except urea before dialysis) with the inflammatory index of the diet. There was no significant relationship between the inflammatory index of the diet with the intake of macronutrients and micronutrients in the raw model and after adjustment. Only a significant negative correlation was observed between the inflammatory index of the diet and the average fiber intake in the whole population and in women after adjustment for confounding factors (for age and body mass index and duration of dialysis). There was a significant negative relationship between the inflammatory index of diet and iron with vitamin B12 in the general population and men. Conclusion: According to the results of the present study, diet showed anti-inflammatory effect in the study population and a significant relationship was observed between the inflammatory index of the diet and the amount of urea before dialysis. Due to the increase in patients with Chronic kidney disease undergoing hemodialysis and chronic and inflammation diseases in these patients, further studies are necessary to determine the relationship between dietary inflammatory index and anthropometric status and metabolic parameters should be performed in hemodialysis patients. However, recommending a diet with anti-inflammatory properties to improve quality of life and prevent chronic diseases in hemodialysis patients can be part of health program. Key word: Dietary inflammatory index (DII (, chronic kidney disease, hemodialysis