Relationship between high-sensitivity C-reactive protein (hs-CRP) and fibrinogen levels with pulmonary function in sever obese patients

Abstract

For determination of the pure effect of obesity and inflammatory markers on lung function it should be assessed without confounding role of diabetes, asthma, chronic heart disease, etc. In this study the association between high-sensitivity C-reactive protein (hs-CRP) and fibrinogen with pulmonary function in patients with severe obesity (BMI ≥ 35 kg/m²) was assessed. Materials and methods: In this descriptive comparative study in Tabriz, Iran, Summer 2019, 36 subjects older than 18 years of age with severe obesity (BMI ≥ 35 kg/m²) and 36 healthy non-obese (BMI < 30 kg/m²) subjects were assessed. The association between high-sensitivity C-reactive protein (hs-CRP) and fibrinogen with pulmonary function in patients with severe obesity (BMI ≥ 35 kg/m²) was assessed and compared with control group. Results: Although hs-CRP was statistically significantly higher in obese patients (BMI above 35 kg / m2) than in healthy non-obese patients (BMI below 30 kg / m2) (P <0.05) but There was no significant correlation between spirometric measurements with hs-CRP and fibrinogen levels (P > 0.05). Mean CRP and fibrinogen levels were not differed in those with pear versus apple body shape but it was higher in apple shapes (P > 0.05).