Evaluation of the measurment of Calprotectin and Calprotectin to total protein ratio in ascitic fluid of cirrhotic patients in determination of prognosis and out come of these patients in a period of six mounth

Abstract

The aim of this study was to evaluate the role of calprotivectin and the ratio of calprotivectin to total protein in the rapid diagnosis of SBP in patients with cyrotic disease and to evaluate the value of calprotivectin in the prognosis of cyrotic patients, including gastrointestinal bleeding or encephalopathy and also the child score of patients with cyrotic disease Methods and Material: In this cross-sectional study, patients with liver cirrhosis who referred to Imam Reza Educational Center of Tabriz were included in the study according to the inclusion and exclusion criteria. The level of calprotivectin in ascites and the relationship between the level of calprotivectin fluid and the ratio of calprotivectin to total protein and the number of neutrophils and changes in the child score were evaluated Results: Of 87 studied patients, 55.2% were female and 44.8% were male. The mean age of the patients was 56.86 ± 16.05 years. The number of WBC and PMN percentage of ascites and calprotectin level ascites and child score at baseline and child score of patients during 6 months and total protein ascites and Alb were 284/82 ± 56/13 , 71/67 ± 23/13 ,185/44 ± 75/21 and 10/36 ± 1/19, 9/52 ± 1/65 and 1/43 ± 0/86, and 0/94 ± 0/69, respectively. Also, the prevalence of SBP positive and negative patients was 29% and 71% , respectively. During the follow-up of 6 months, 36 patients died and 51 of the patients were alive. The comparison between the two groups of patients dead and alive, based on statistical analysis, showed a significant difference between the two groups in terms of levels of calprotectin and total protein ascites and albumin and child score at baseline and child score the patients during the follow-up of six Patients score at the time of admission and the child score of patients during six months follow up (P-value <0.05). The comparison between the two groups of patients with positive and negative SBP results, based on statistical analysis, showed a significant difference between the two groups in terms of levels of calprotectin and total protein ascites and albumin and child score at baseline and child score the patients during the follow-up of six Patients score at the time of admission and the child score of patients during six months follow up (P-value <0.05).