Evaluation of Antibiotic prophylactic regimen in surgical patients in Sina Hospital affiliated to Tabriz University of Medical Sciences during 6 month period

Abstract

Introduction: Antibiotic prophylaxis before various surgeries plays a pivotal role in the prevention of infection. Inappropriate antibiotic prophylaxis may lead to life-threatening infections and development of resistant micro-organisms which affect surgical outcomes and increase morbidity and mortality. Aim: Evaluation of antibiotic prophylactic regimens and comparing them with ASHP & IDSA standard guidelines in patients undergoing various surgeries in Sina Hospital, affiliated to Tabriz University of Medical Sciences. Methods: This was a prospective cross-sectional study conducted during a 6-months period on patients undergoing surgeries in Sina Hospital of Tabriz University of Medical Sciences. Medical files of 311 randomly-selected patients were assessed regarding prophylactic antibiotic regimens. Demographic data, history of co-morbid diseases and drugs as well as type, dosage, time and duration of antibiotic prophylaxis were assessed and compared to those described in the ASHP & IDSA standard protocols. Results: Among 311 studied patients, 44. 6% were women and55. 3% were men. Abdominal surgery was the most common type of surgery among surgeries needing prophylactic antibiotic and clean plastic surgery was the most common type of surgeries that did not need prophylactic antibiotic. Errors in prophylactic initial dose (85. 7%), duration (76. 8%%) and timing of first dose (58. 3%) were common and very high. 0. 3% of patients had infection signs and symptoms. Just one real infection case was reported during 6 months. Conclusions: Antibiotic prophylaxis parameters including initial dose, timing of initial dose, duration and choosing appropriate regimen showed 0. 6%, 23. 8%, 23. 2%, and 63. 69% consistency with ASHP & IDSA guidelines respectively. Despite not having an indication for antibiotic prophylaxis,6. 2% of patient received antibiotic prophylaxis.