Comparing Effect of the Second and Third Generation Combine Oral Contraceptives on Mood and Sexual Function (Double –Blind Clinical Trial).

Abstract

Abstract: Objective: The aim of this study was to compare effects of the second and the third generations of oral contraceptive on adolescent woman's mood and sexual function. Study Design: This randomized, double –blind, placebo –controlled clinical trial was conducted on 82 adolescent women at health centers in East of Tehran. Samples were randomized into the second and the third generations receiving oral contraceptive groups. Positive and negative moods were recorded using, Positive affect, Negative Affect Scale (PANAS) tool and Female Sexual Function Index (FSFI) before intervention and two months, and four months after intervention. Data analysis was carried out using ANOVA with Repeated Measure and P values<0.05 was considered significant. Results: There was a statistically significant difference in positive and negative moods and sexual function between the experimental and control groups before intervention in the second month and the fourth month. The second generation oral contraceptive had resulted in a significant decrease of positive mood and increase of negative mood in the second month and the fourth month, but the third generation had led to an increase of positive mood and a decrease of negative mood. The second generation had resulted in a decrease in sexual function in the second month and an increase in sexual function in the fourth month, but the third generation led to an increase in sexual function in the second and fourth months. The increase in sexual function resulted from using the third generation was significantly higher than the second generation. An intra –group comparison showed significant difference of the exact of positive and negative mood and sexual function between the two groups in the three periods of time. Conclusion: Based on the findings, it is possible to provide women with awareness of the probable effects of oral contraceptive on mood and sexual function by developing educational and consultation programs in family planning centers.