Resistance investigation of E.coli to fluoroquinolones and cotrimoxazole in isolates of Sina educational and treatment centers Tabriz university of medical science

Abstract

The aim of the present study was to evaluate the resistance of E.coli to fluoroquinolones and cotrimoxazole in isolates of Sina educational and medical center of Tabriz University of Medical Sciences. Materials and Methods: From patients who had referred to the Sina Hospital, they had at least one of the symptoms of fever, sepsis, bacteremia or dysuria, urinary frequency. Blood, urine, wound and fluid cultures were done. Samples in which the E-coli grew were included in the study. 153 samples were obtained and microbial identification, culture, antibiogram and E-test were performed. Results: E.coli isolates possessed highest sensitivity towards nitrofurantoin (97.1%), imipenem (96.5%), amikacin (95.7%), piperacillin-tazobactam (92.6%) and tobramycin (81.8%). The highest resistance was observed for cefazolin (97.3%), ampicillin (92.5%) and cefepime (83.3%, respectively). MIC was also determined for fluoroquinolones and cotrimoxazole. In the present study, the average resistance to fluoroquinolones was 66.7% and co-trimoxazole resistance was seen in 58.8% isolates.