Comparison of Intravenous Administration of Ondansetron Versus Ephedrine for Prevention of Spinal Anesthesia-Induced Hypotension in Caesarean Section

Abstract

Recently, the effect of serotonin receptor blockers such as endonsterone in preventing spinal hypotension, especially in pregnant women, has been considered; Therefore, the aim of the present study was to compare venous Ondansetron with ephedrine in the prevention of hypotension due to spinal anesthesia in selective cesarean section. Materials and Methods: This randomized clinical trial was performed with the participation of 100 women (using sample size formula - available sampling) after elective cesarean section randomly assigned to two groups of Ondansetron and Ephedrine in 18 months ending September 1398 in Tabriz Alzahra Hospital. Immediately after anesthesia injection, 4 mg of injectable and 10 mg of ephedrine were injected into each group. Blood pressure status during surgery for each group was recorded in each instrument and the data were analyzed by T-test and Mann-Whitney U and Chi-square tests. SPSS22 was used for comparison. P value less than 0.05 was considered significant. Results: The results showed that systolic and diastolic blood pressure was significantly higher in ephedrine group (p=0.03 and p=0.04) but there was no difference in mean arterial pressure and heart rate (p>0.05). However, the need for intraoperative vasopressor to treat hypotension during surgery and its frequency of injections in the Ondansetron group was significantly lower (p=0.003). Also, side effects during and after surgery (nausea, vomiting, agitation, chills) were lower in the Ondansetron group.