The Effect of Intravenous Hydration on AFI in Pregnant Women with Preterm Premature Rupture of Membranes.

Abstract

Abstract: Background and Objectives: Preterm premature rupture of membranes (PPROM) is a frequent obstetrical incident which can result in maternal and fetal complications. This study aimed to determine the effects of intravenous fluid bolus on amniotic fluid index (AFI) in pregnant women with PPROM. Methods: Twenty –four women with PPROM during singleton live pregnancy of 28 to 34 weeks whose AFI was ≤5cm were randomized into two groups. Baseline AFI was measures in all women. The study group received a 1 liter intravenous fluid bolus of isotonic serum over a 30 –minute period. The control group received routine management. A particular examiner blinded to the groupings repeated the examination 90 minutes and 48 hours later. Results: AFI decreased at 90 minutes in both groups. However, this decrease was statistically significant only in the control group (p<0.05). AFI decreased at 48 hours after hydration in both groups. This decrease was not statistically significant in any group. The differences in ∆AFI (90 minutes and baseline) and (48 hours and baseline) between the two groups were not significant (p=0.18), (p=0.77) respectively. The time between mean baseline measurements and delivery were 196.41 and 140.58 hours in the study and control groups, respectively. This difference was not statistically significant (p=0.49). Conclusion: Intravenous fluid bolus prevents substantial decreases of AFI. However, mean difference in AFI between the two groups was not statistically significant. Therefore, the procedure cannot be advised as a routine treatment for PPROM. Running title: Intravenous Hydration on AFI.