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dc.contributor.advisorMohajjel Nayebi, Alireza
dc.contributor.authorJabbarpour, Reza
dc.date.accessioned2021-03-01T07:49:19Z
dc.date.available2021-03-01T07:49:19Z
dc.date.issued2021en_US
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/63773
dc.description.abstractIntroduction: In the process of neuropathy induced by anticancer drugs, several mechanisms have been mentioned such as activation of the oxidative stress system, increasing the activity of NMDA receptors, and serotonin receptors. Neuropathic pain is a result of various mechanisms operating at the peripheral, spinal cord and supra-spinal levels, which cause alterations in the pain conduction pathway. This may also develop secondary to some other pathological conditions such as diabetes mellitus, cancer, herpes infection, autoimmune diseases and HIV infection etc. Goal: The aim of the current study was to evaluate the preventive effects of pentoxifylline and pregabalin on vincristine-induced neuropathic pain that was the result of vincristine in the (spurious) mice. Materials and methods: 81 male mice in a weight range of 25 to 35 grams were randomly divided into 9 equal groups and underwent pentoxifylline and pregabalin for 25 days. Different doses of pentoxifylline and pregabalin were injected three days before injection of vincristine (1 mg/kg,IP ) at 4th day. Then injection of pentoxifylline and pregabalin continued for 3 days. After that we have 3 days for rest. Finally we performed hot plate test. This 7 day cycle repeated 3 times for all groups. At day 25, blood samples were collected for MDA and TAC estimation. Result: The results showed a meaningful increase in reaction to the pain injection of these doses (25, 50, 100 mg/kg, IP) of pentoxifylline and pregabalin (5,10,20 mg/kg, IP) and also the meaningful impact of pentoxifylline in these doses (25, 50, 100 mg/kg, IP) can decrease MDA level. Also, injecting low doses of these two drugs together had a better effect than injecting these two drugs alone. Conclusion: It is probable that a part of the inhibitory effects of pentoxifylline is mediated by the control of oxidavtive stress. At the same time, we suggest further studies to obtain precise mechanisms.en_US
dc.language.isofaen_US
dc.publisherTabriz University of Medical Sciences, School of Pharmacyen_US
dc.relation.isversionofhttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/63772en_US
dc.subjectVincristineen_US
dc.subjectNeuropathyen_US
dc.subjectpentoxifyllineen_US
dc.subjectpregabalinen_US
dc.subjectMale Miceen_US
dc.titlePreventive effects of Pentoxifylline and Pregabalin on neuropathic pain induced by Vincristine in miceen_US
dc.typeThesisen_US
dc.contributor.supervisorHabibi Asl, Bohloul
dc.contributor.supervisorAzarmi, Yadollah
dc.identifier.callno218en_US
dc.description.disciplinePharmacyen_US
dc.description.degreePharm Den_US


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