The impact of bismuth / gold core / shell nanoparticles in efficiency of breast cancer in Balb/C mouse radiation therapy

Abstract

In this study, use of High atomic number Z, nanoparticles are able to increase of radiation therapy efficacy we prepared Bi2S3-Au heterodimers with a Schottky barrier and hopeful capability of the generation of free radicals for selectively improving radiotherapeutic efficacy in the tumors .particles coated with bovine serum albumin (BSA) were prepared through a BSA-mediated biomineralization procedure under green conditions. We explain the use of folic acid (FA) functionalized, BSA-modified Bi2S3-Au heterodimers (Bi2S3-Au-BSA-FA hybrids) as a targeted radiosensitizer for breast cancer therapy in the murine model. The Bi2S3-Au-BSA-FA system has combined and collected the ability of enhanced X-ray radiation therapy (Bi2S3-Au), long blood circulation time (BSA), tumor targeting (FA). The FA functionalized Bi2S3-Au heterodimer demonstrated in vitro and in vivo tumor enhanced radio sensitization. When the tumors were irradiated 24 h after receiving the Bi2S3-Au-BSA-FA hybrids, not only significant tumor inhibition was seen but also the survival ratio was increased in mice. Furthermore, the tumor bearing mice experienced a more effective tumor rejection when they received Bi2S3-Au-BSA-FA hybrids + X-ray irradiation than both of the Bi2S3-BSA + X-ray and Au + X-ray groups. Which was significantly better than the currently reported works