Relation of Neutrophil to Lymphocyte Ratio to Response to Thrombolysis in Patients with Prosthetic Valve Thrombosis Receiving Fibrinolytic Therapy

Abstract

The aim of present study was to investigate the relationship between the effects of neutrophil to lymphocyte ratio (NLR) on thrombolysis response in patients with fibrinolytic-treated prosthetic valve thrombosis. Materials and methods: In a cross-sectional study, all patients referred to Shahid Madani Educational-Medical Center of Tabriz University of Medical Sciences due to prosthetic valve thrombosis during 2003-2017 who had undergone fibrinolytic treatment were included in the study. The records of all patients are reviewed and the study checklist includes demographic information and clinical information such as valve location, time of valve replacement to thrombosis, patient rhythm, echocardiographic findings, laboratory findings such as WBC number and its categories (lymphocytes and neutrophils) as well as patients' outcome including important in-hospital complications such as mortality, bleeding and recurrence of thrombosis were recorded based on patients' clinical records. Results: Among the 33 patients studied, 23 patients (69.7%) were female and 10 patients (30.3%) were male. The mean age of patients was 51.69±12.46 years. Mitral valve was the most common site of thrombosis (84.8%). The mean NLR of patients was 5.59±5.01 and 22 patients (66.7%) had a successful response to thrombolysis treatment. The mean NLR in patients with successful response to thrombolytic therapy was 4.29±3.78 and in patients without successful response was 8.21±6.26 (P = 0.036). The mean NLR was 8.88±7.11 in patients with bleeding and 4.54±3.74 in patients without bleeding (P=0.049).