CA19-9 serume levels in patients with UC in compare with healthy control group and its relationship with PSC

Abstract

The aim of this study was to investigate the relationship between serum CA19-9 levels in patients with IBD, especially those with ulcerative colitis, and the progression of this disease to PSC. material and methods: This descriptive study was performed at Imam Reza Hospital and Sina Hospital in Tabriz from 2015 to 2016.Statistical population included all patients with ulcerative colitis referred to IBD clinic and serum CA19-9 level was measured. 192 patients with IBD were included in the study. A total of 208 healthy controls were included in this study and serum levels of CA19-9 were evaluated in both patient and healthy groups. Results: 6/77% of patients had PSC and 24/47% had other extraintestinal manifestations of IBD. Among healthy controls, 7 patients had a serum level of CA19-9 above normal, above 37. The results showed that the serum level of CA19-9 was significantly higher in patients with PSC than in patients with other extraintestinal manifestations of IBD, 93 versus 11 or in patients without extraintestinal manifestations 93 versus 7/15.