The Comparison between Induction Effect with Pulsatile and Continuous Oxytocin Administration on Outcomes of Pregnancy in Pregnant Women referring to Tabriz, 29 Bahman Hospital in 2006.

Abstract

Abstract: Introduction: Insufficient uterine activity or hypotonic uterine contraction is a common reason and the cause of abnormal labor progress that we can be correct with oxytocin and do vaginal delivery. Realizing this fact that undue prolongation of labor may contribute to mortality caused using of oxytocin infusion in different kinds of perinatal morbidity and ineffective uterine contraction. Material & Method: In this study, one hundred pregnant women in 29 Bahman hospital has participated in a Quasi –experimental research and were divided randomly into 2 groups (pulsatile induction and continuous induction) and were compared pregnancy outcomes include progress of labor, hyperstimulation, type of delivery, third stage duration, newborn's Apgar score and hyperbilirubinemia. Tool of study was partogram and a questionnaire consisted of two part: the first section was related to demographic and fertility characteristics. The second section was related to researcher's observations during sampling and obtaining of induction and laboratory tests. Data were analyzed by inferential statistic (percent's and frequency distribution tables), independent samples t test, x2, fisher's exact test by SPSS15 software. Results: There were no significant differences between two groups in demographic and fertility characteristics and progress of labor, hyperstimulation rate, newborn's Apgar score and hyperbilirubinemia. But we found a significant difference in labor duration (p=0.022), type of delivery (p=0.008) and dose of oxytocin (total dose & maximum dose) (p<0.0005). Conclusion: According to findings of this study, administration of oxytocin with the feedback pulsatile oxytocin system is easier and more physiologic to establish the effective uterine contraction and reduce duration of labor. Thus it reduces mothers fatigue and labor dystocia and cesarean section rate. In addition, the average dose of oxytocin administered is significantly less in pulsatile induction group that it can causes reducing of complications related to oxytocin dose which may afford a greater margin of safety of mother and fetus.