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dc.contributor.advisorAlivand, Mohammadreza
dc.contributor.authorSheikhkanlou, Parisa
dc.date.accessioned2021-01-27T09:58:58Z
dc.date.available2021-01-27T09:58:58Z
dc.date.issued2020en_US
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/63429
dc.description.abstractGenetic changes play an important role in the development of gastric cancer. In addition to changes in the level of DNA, changes in the expression level of MicroRNAs are also important in cancer progression. It is understood that the intercommunication between cancer cells and their microenvironment is essential to tumor angiogenesis. Exosomes are extracellular vesicles that are important mediators of intercellular communication and play a role in promoting angiogenesis. However, very little is known about the contribution of breast cancer exosomes to tumor angiogenesis or whether exosomes can mediate docetaxel (DTX)’s anticancer action. Methods: HUVEC cell line was cultured in complete RPMI-1640. Cells were treated for 24 hours with DTX, CoCl2, DTX and CoCl2. Cells were harvested, and RNA extraction and cDNA synthesis were performed from cells and exosomes using standard methods. Expression levels of miRNAs and their pro-angiogenic target genes were analyzed using quantitative real-time PCR (qRT-PCR). Results: We observed a decrease in the expression of pro-angiogenic gene including VEGF in cells after treatment with DHA in normoxic and hypoxic condition. And also the expression of tumor suppressor miRs including miR-16, miR-152 was altered by DTX in treated cells.en_US
dc.language.isofaen_US
dc.publisherTabriz University of Medical Sciences, Faculty of Medicineen_US
dc.relation.isversionofhttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/63428
dc.subjectCanceren_US
dc.subjectAngiogenesisen_US
dc.subjectDTXen_US
dc.subjectmicroRNAen_US
dc.titleStudy of the anti-proliferative and anti-migratory response of endothelial cells to the treatment with Docetaxel anti-cancer agenten_US
dc.typeThesisen_US
dc.contributor.supervisorShirmohammadi, Masoud
dc.contributor.supervisorKazemi, Tohid
dc.identifier.docno609736en_US
dc.identifier.callno9736en_US
dc.description.disciplineMedicineen_US
dc.description.degreeM.D Degreeen_US


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