COVID-19 severity in patients treated with immunosuppressive medications refereed to Imam Reza Educational and Medical Center

Abstract

The aim of this study is to investigation of COVID-19 severity in patients treated with immunosuppressive medications refereed to Imam Reza Educational and Medical Center. Materials and Methods: This was a descriptive-analytical cross-sectional study and all patients with rheumatism who were treated with immunosuppressive drugs and were hospitalized in Imam Reza Educational and Medical Center of Tabriz, from March 2020 to July 2020 due to Covid-19 disease (411 patients), were selected. Demographic (age, sex, etc.) and clinical characteristics of patients were extracted from their clinical records or by interviewing patients. The prevalence of patients treated with immunosuppressive drugs with outpatient treatment will be estimated as hospitalized in the ward, hospitalized in the ICU, or died. Results: In this study, among the variables related to demographic, clinical and laboratory characteristics and results in the two groups of autoimmune patients treated with immunosuppressive drugs and patients without treatment with immunosuppressive drugs, the variables of age (P-value = 0.020) and lymphopenia (P -value = 0.015) was significantly higher in the group of patients without treatment with immunosuppressive drugs than in the group of autoimmune patients treated with immunosuppressive drugs and the variables of sex ratio (P-value = 0.001), dyspnea (P-value = 0.036), myalgia (P-value = 0.006), malaise (P-value = 0.001), taste loss (P-value = 0.001), anosmia (P-value = 0.001) in the group of autoimmune patients treated with immunosuppressive drugs was significantly higher than the group of patients without treatment with immunosuppressive drugs; But the variables of fever, cough, nausea / vomiting / diarrhea, anorexia, sore throat, high C-reactive protein, level of care (admitted in ward, admitted in ICU and Intubated and mechanically ventilated), the time interval from onset of symptoms to admission and mechanical ventilations, duration of admission in ICU, duration of intubation and mortality were not statistically different between the two groups (P-value> 0.05).