surgical repair of nasal septal perforation by mucosal rotational flap and interposition of human amniotic membrane

Abstract

Background: The surgical repair of nasal septal perforations has always been a challenging procedure and no consensus has been made about a definitive protocol. In the current study, we investigated the use of multilayered human amniotic membrane with mucosal rotational flap for the surgical repair of nasal septal perforations. Methods: In this prospective clinical study, 12 patients with symptomatic nasal septal perforation underwent surgical repair, between December 2018 and October 2019. The surgical procedure comprised of a rotational flap on one side of the defect and multilayered human amniotic membrane as an interpositional graft in the mucoperichondrial pocket on the other side. The patency of defect was checked at a follow-up appointment at least 3 months after surgery. Results: Successful repair was perceived in 10 of 12 (83%) of patients. Reperforation occurred in two patients but the size of the defect was smaller. All of the patients reported elimination of all symptoms associated with nasal septal perforation. Conclusion: The use of human amniotic membrane as an interpositional graft accompanied by a mucosal rotational flap seems to be efficient in alleviating the symptoms of nasal septal perforation and closure of the defect.