Comparison of Health Promoting Behaviors and Serum Levels of Some Antioxidants in Healthy Fertile Women with Infertility Women of Unknown Etiology: A Case-Control Study Supervisors

Abstract

Abstract: Background and Aim: Health-promoting lifestyle training and modification of serum antioxidants can be effective in reducing the risk factors of infertility. The purpose of this study was to determine the relationship between health promoting behaviors and serum levels of some antioxidants with idiopathic infertility. Methods: This study is a case-control study performed on idiopathic infertile women referring to infertility clinics affiliated to the University of Medical Sciences and Healthy Fertile Women. Twenty-four eligible cases were included in the case group and 3 times the case group, ie 72 eligible for the control group after adjusting for age, education, body mass index (BMI), income, choice Were. Data were collected by the participants demographic, anthropometric, midwifery questionnaires and health promotion lifestyle questionnairesSerum levels of malondialdehyde (MDA) and total antioxidant capacity (TAC) were evaluated. Data analysis was done by SPSS / version 24 software using descriptive and analytical statistics including chi-square, independent t-test, Fisher exact test, Mann-Whitney, and multivariate logistic regression. P <0.05 was considered significant. Results: There was no significant difference in demographic and social characteristics between the two groups (P >0.05). The mean (standard deviation) overall score of health promoting lifestyle in the fertile women was 140.22 (23.21) and in the infertile women 133.02 (21.12) which was not statistically significant between the two groups. (P = 0.158). The mean (standard deviation) serum TAC level in fertile women was 1.02 (0.16) mmol/l and in infertile women was 0.90 (0.31) mmol/l. Logistic regression analysis with controlling for confounding variables showed that by one unit increase in TAC the risk of infertility in these women was reduced by 93%; P = 0.040) (0.01 to 0.88; Adjusted OR (95% CI): 0.07). The mean (standard deviation) level of serum MDA in fertile women was 1.13 (0.44) nmol/ml and in infertile women was 1.43 (0.32) nmol/ml. Adjusted OR (95% CI): 4.48 (1.35 to 14.87), based on one-unit logistic regression test with malondialdehyde (MDA (4.5 times higher risk of infertility in these women; P = 0.014)). The mean (standard deviation) serum zinc level in fertile women was 91.81 (35.18) μg/dl and in infertile women (28/39) was 79/61 μg/dl. (P = 0.194). The median (interquartile) serum level of vitamin D in the fertile women was 27.75 (29.10) ng/ml and in the infertile women 36.27 (21.94) ng/ml; p = 0.033)) adjusted OR (95% CI): 0.99 (0.97 to 1.0)). Conclusion: The results of this study showed that with increasing TAC the risk of infertility decreases and with increasing MDA the risk of infertility increases. There was no significant relationship between primary infertility and lifestyle. Therefore, since there is a significant relationship between oxidative stress and infertility, identifying the main causes of oxidative stress and reducing them can help reduce infertility.