Autoimmune Thyroid Disease in Women with Ages between 35 to 45 years based on data Azar Cohort

Abstract

In this study we aim to evaluate the autoimmune thyroid disease in women with ages between 35 to 45 years based on Azar Cohort study data. Methods: In this cross-sectional analytical study, 507 women 35-45 years old without previous thyroid disease from Azar Cohort study were evaluated. Demographic findings, data related to previous pregnancies, abortion, miscarriage, infertility and gestational diabetes were recorded for all patients. Blood samples were taken from all patients to measure TSH and anti-TPO levels. Anti-TPO levels ≥40 IU/ml were considered positive. Results: In the studied women, ¬Stillbirth occurred in 5.3%, abortion in 27.6% and infertility in 7.3%. Gestational diabetes was reported in 3.9%. The positive Anti-TPO prevalence was 21.5%. Patients with positive anti-TPO compared to those with negative anti-TPO had significantly higher cases of hypothyroidism (p<0.001). There was no difference between patient with and without positive anti-TPO regarding miscarriage (5% vs. 6.4%), abortion (27.4% vs. 28.4%), infertility (7.5% vs. 6.4%) and gestational diabetes (7.9% vs. 3.6%) (p>0.05). There was no correlation between age and anti-TPO levels.