Effects of Melatonin on ischemia-reperfusion injury and the Klotho protein expression in renal transplant patients

Abstract

The current study aimed at determining the anti-inflammatory and anti-oxidative effects of melatonin on the complications of IRI and the level of Klotho expression in these patients. Material and Method: Candidates for kidney transplantation received a dose of 3 mg per day of melatonin. Then serum melatonin levels, inflammatory and oxidative stress factors, renal function biomarkers, and Klotho gene/protein expression were masured by venous blood samples. Result: Melatonin was associated with improvement in renal transplantation, since the serum level of neutrophil gelatinase-associated lipocalin, as a renal functional marker, significantly decreased (P <.001). The effect of melatonin as a suppressor of inflammation and oxidative stress was also evident in the melatonin group due to a significant reduction in the serum levels of MDA, CP, 8-OHdG, and TNF-α (P <.001).