Glucose tolerance status in patients with newly diagnosed papillary thyroid carcinoma

Abstract

The aim of this study was to determine the prevalence of glucose tolerance disorder in patients with PTC and to compare the association between insulin resistance and disease severity, lymph node involvement and metastasis. Materials and Methods: In this cross-sectional study, 68 patients with the diagnosis of PTC were enrolled. The presence of metastasis was evaluated by whole body scan and ultrasound studies used to assess the cervical lymph node status. Then in all patients in order to determine the Insulin resistance, 75 g glucose was administered orally and after two hours, serum glucose level was measured. The obtained data were analyzed by SPSS software. Results: Of the 68 patients, 76.5% were female and 23.5% male. The mean age of the patients was 44.2±13.8 years. The mean fasting blood sugar level in patients was 103.21±14.8 mg/dl and the mean blood glucose in patients two hours after administration of oral glucose was 145.12±22.37 mg/dl. 25% of patients had lymph node involvement, the correlation between presence of Insulin Resistance and Lymph node involvement was statistically significant (p = 0.03). Metastasis observed in 16.2% of patients, which was significantly higher in patients with glucose intolerance (p <0.05).