Evaluating the effect of nanoparticles with polycaprolactone_ polyethylene glycol smart polymeric shell with capability of loading two drugs (Docetaxel and Doxorubicin) on kidney factors, liver enzymes, blood factors and antioxidants in head and neck squamous cell carcinoma: an animal study

Abstract

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide and is associated with high mortality rate. Docetaxel and Doxorubicin have been proved to be efficient therapy for HNSCC. Intravenous administration of the chemotherapeutic agents has adverse effects not only on cancerous cells but also on normal tissues and organs, and increase the possibility of toxicity in these tissues. As a novel therapeutic strategy, the use of nanoparticles as a drug delivery system provide an opportunity to deliver a large amount of drugs directly to the target cancerous cells.

Aims: The aim of this study was to investigate the effect of Docetaxel and Doxorubicin loaded nanoparticles on antioxidant profile, blood cells and kidney and liver function in oral squamous cell carcinoma in animal models.

Materials and Methods: In this study 4 groups were studied including group 1, healthy mice, group 2, untreated cancerous mice, group 3, mice treated with free form of Docetaxel and Doxorubicin and group 4, mice treated with nanoparticles carrying Docetaxel and Doxorubicin. Results: There was 0a significant difference in antioxidants, blood cells, liver and kidney function indices between groups, i.e. UREA and ALP enzymes were significantly higher in mice treated with free form of drugs than in the healthy and cancerous mice (P-value<0.05). Concludion: The results of this study showed that nanoparticle form of drugs was less toxic than free form.