Evaluation of the relation between Serum and saliva levels of sodium and glucose in healthy referred patients to Tabriz Faculty of Dentistry

Abstract

Introduction: The use of salivary compounds due to non-invasive has provided a suitable tool for the replacement of blood components. Due to the importance of sodium and glucose levels in many biological processes, this study evaluated the relation between serum and saliva levels of sodium and glucose in non-diabetic patients referred to Tabriz faculty of dentistry.

Methods: This descriptive study was conducted on 40 patients referring to Tabriz Dental School. These patients were extracted according to standard protocols of serum and salivary. Data were presented mean (± standard deviation) and frequency (percentages) for quantitative and qualitative variables, respectively. Statistical analysis was performed by SPSS19 software. To determine the correlation between serum and salivary levels of biomarkers was performed Pearson test by SPSS 24 software. The significance level of P <0.05 was considered.

Results: From 40 subjects we studied there were 26 women and 14 men. The average obtained for serum sodium (141.72 mg/dl) , which was higher than the average of salivary sodium (127.53 mg/dl) , and the average of serum glucose was ( 89.4 mg/dl) ,which was higher than the average salivary glucose (4.05 mg/dl) .The result of paired samples T test ( p-value<0.05) showed that there is a statistically significant difference between the mean of serum sodium and salivary sodium ,as well as between the serum glucose and salivary glucose. Pearson correlation test results showed that there is no significant correlation between serum sodium and salivary sodium (p-value >0.05) , but here is a positive correlation between serum glucose and salivary glucose (p-value<0.001). Both serum sodium and glucose were higher than salivary sodium and glucose.

Conclusion: It is important to measure accurately the blood factors with the least damage to them. The study found that there was not a statistical relationship between salivary glucose and blood of non-diabetic individuals. Perhaps salivary samples can’t be used to measure glucose in these individuals.